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2-amino-7-(1-methylethyl)-5-oxo-5H-chromeno[2,3-b]pyridine-3-carboxylic acid

Amlexanox

CAS: 68302-57-8

Molecular Formula: C16H14N2O4

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2-amino-7-(1-methylethyl)-5-oxo-5H-chromeno[2,3-b]pyridine-3-carboxylic acid - Names and Identifiers

Name Amlexanox
Synonyms aa-673
amoxanox
Aphthasol
AMLEXANOX
Amlexanox
RARECHEM AL BO 1376
2-Amino-7-isopropyl-1-azaxanthone-3-carboxylic Acid
2-Amino-7-isopropyl-5-oxo-5H-chromeno[2,3-b]pyridine-3-carboxylic acid
2-amino-5-oxo-7-(propan-2-yl)-5H-chromeno[2,3-b]pyridine-3-carboxylic acid
2-Amino-7-isopropyl-5-oxo-5H-[1]benzopyrano[2,3-b]pyridine-3-carboxylic Acid
2-amino-7-(1-methylethyl)-5-oxo-5H-chromeno[2,3-b]pyridine-3-carboxylic acid
5h-(1)benzopyrano(2,3-b)pyridine-3-carboxylicacid,2-amino-7-(1-methylethyl)-5
2-Amino-7-(1-methylethyl)-5-oxo-5H-[1]benzopyrano[2,3-b]pyridine-3-carboxylicAcid
2-Amino-7-(1-methylethyl)-5-oxo-5H-[1]benzopyrano[2,3-b]pyridine-3-carboxylic Acid
5H-[1]benzopyrano[2,3-b]pyridine-3-carboxylic acid, 2-amino-7-(1-methylethyl)-5-oxo-
CAS 68302-57-8
EINECS 804-135-3
InChI InChI=1/C16H14N2O4/c1-7(2)8-3-4-12-9(5-8)13(19)10-6-11(16(20)21)14(17)18-15(10)22-12/h3-7H,1-2H3,(H2,17,18)(H,20,21)

2-amino-7-(1-methylethyl)-5-oxo-5H-chromeno[2,3-b]pyridine-3-carboxylic acid - Physico-chemical Properties

Molecular FormulaC16H14N2O4
Molar Mass298.29
Density1.408±0.06 g/cm3(Predicted)
Melting Point>3000C
Boling Point570.0±50.0 °C(Predicted)
Flash Point298.5°C
Solubility DMSO: soluble10mg/mL at warmed, clear
Vapor Presure7.86E-14mmHg at 25°C
Appearancepowder
Colorwhite to beige
Merck14,490
pKa3.95±0.20(Predicted)
Storage Condition-20°C
StabilityStable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 3 months.
Refractive Index1.668
Physical and Chemical PropertiesWhite to yellowish white crystals or crystalline powder, odorless and tasteless. Soluble in dimethyl sulfoxide, more soluble in dimethyl formamide, difficult to dissolve in Tetrahydrofuran, very difficult to dissolve in methanol, ethanol or chloroform, a few insoluble in ether, acetonitrile or water. Melting point> 300 °c. Acute toxicity LD50 mice, rats (mg/kg):2320~2370, about 10000 oral.
UseFor the treatment of oral ulcers

2-amino-7-(1-methylethyl)-5-oxo-5H-chromeno[2,3-b]pyridine-3-carboxylic acid - Risk and Safety

Hazard SymbolsXn - Harmful
Harmful
Risk CodesR22 - Harmful if swallowed
R43 - May cause sensitization by skin contact
Safety DescriptionS36/37 - Wear suitable protective clothing and gloves.
S37 - Wear suitable gloves.
S36 - Wear suitable protective clothing.
WGK Germany3
RTECSDJ3102000
HS Code29349990

2-amino-7-(1-methylethyl)-5-oxo-5H-chromeno[2,3-b]pyridine-3-carboxylic acid - Reference Information

biological activity Amlexanox (AA-673, CHX-3673, Amoxanox) is an anti-inflammatory and anti-allergic immunomodulator, it is also an inhibitor of protein kinases TBK1 and IKK-Epsilon.
TargetValue
Use has an inhibitory effect on histamine free reaction, an inhibitory effect on leukotriene production, and an antileukotriene effect, thereby producing an antiasthmatic effect. For the treatment of bronchial asthma, allergic rhinitis.
for the treatment of oral ulcers
production method in an aqueous solution containing morpholine and dimethylformamide, the reaction was heated at 60 ° C. To obtain compound (II). It is condensed and cyclized with malonic acid monoethyl ester amide, and then hydrolyzed to obtain ammonia.
Last Update：2024-04-10 22:29:15
2-amino-7-(1-methylethyl)-5-oxo-5H-chromeno[2,3-b]pyridine-3-carboxylic acid
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Email: product@acmec-e.com
Mobile: +86-18621343501
QQ: 2881950922 Click to send a QQ message
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Hefei TNJ Chemical Industry Co.,Ltd.
Product Name: Amlexanox Request for quotation
CAS: 68302-57-8
Tel: 0086-551-65418684
Email: sales@tnjchem.com
　　　　 info@tnjchem.com
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Shanghai Macklin Biochemical Co., Ltd
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CAS: 68302-57-8
Tel: +86-18821248368
Email: Int06@meryer.com
Mobile: +86-18821248368
QQ: 495145328 Click to send a QQ message
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Shanghai Yuanye Bio-Technology Co., Ltd.
Multiple SpecificationsSpot supply
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CAS: 68302-57-8
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
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View History
2-amino-7-(1-methylethyl)-5-oxo-5H-chromeno[2,3-b]pyridine-3-carboxylic acid
590355-50-3
81600-02-4
4-Isoquinolinecarboxylic acid, 3-(dimethylamino)-1,2-dihydro-1-oxo-, 2,2,2-trifluoroethyl ester
948294-62-0
499197-90-9
15851-87-3
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